Publications

Principals about principal components in statistical genetics

Abegaz F, Chaichoompu K, Génin E, Fardo DW, König IR, Mahachie John JM, Van Steen K. Brief Bioinform. 2018 Sep 14. doi: 10.1093/bib/bby081. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30219892

New insights into the complex role of mitochondria in Parkinson’s disease

Grünewald A, Kumar KR, Sue CM. Prog Neurobiol. 2018 Sep 13. pii: S0301-0082(18)30065-0. doi: 10.1016/j.pneurobio.2018.09.003. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30219247

A Klinefelter patient with an additional mitochondrial mutation: Implications for genotype-driven treatment and mitochondrial mutational load in different tissues and family members

Dulovic M, Schäffer E, Leypoldt F, Balck A, Schaake S, Hinrichs F, Kirchner H, Brüggemann N, Berg D, Lohmann K. Parkinsonism Relat Disord. 2018 Sep;54:116-118. doi: 10.1016/j.parkreldis.2018.04.001. Epub 2018 Apr 3. https://www.ncbi.nlm.nih.gov/pubmed/29650490

Parkin and PINK1 mitigate STING-induced inflammation

Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Nature. 2018 Sep;561(7722):258-262. doi: 10.1038/s41586-018-0448-9. Epub 2018 Aug 22. https://www.ncbi.nlm.nih.gov/pubmed/30135585

Mendelian randomization: Progressing towards understanding causality

König IR, Greco FMD. Ann Neurol. 2018 Aug;84(2):176-177. doi: 10.1002/ana.25293. Epub 2018 Aug 25. https://www.ncbi.nlm.nih.gov/pubmed/30014502

Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics

Wohlers I, Bertram L, Lill CM. J Autoimmun. 2018 Nov;94:83-89. doi: 10.1016/j.jaut.2018.07.010. Epub 2018 Aug 22. https://www.ncbi.nlm.nih.gov/pubmed/30143393

Disease-causing or benign? challenges in genetic variant interpretation and limitations of ClinVar

Petkovic S, Lohmann K. Mov Disord. 2018 Aug;33(8):1271. doi: 10.1002/mds.94. https://www.ncbi.nlm.nih.gov/pubmed/30230623

An integrated OMICS approach unravels the elusive genetic cause of X-linked dystonia-parkinsonism

Reyes CJ, Westenberger A. Mov Disord. 2018 Jul;33(7):1095. doi: 10.1002/mds.27458. https://www.ncbi.nlm.nih.gov/pubmed/30153393

Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism

Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D4, Rolfs A, Seibler P, Westenberger A, König I, Klein C. Mov Disord. 2018 Jul;33(7):1108-1118. doi: 10.1002/mds.27441. https://www.ncbi.nlm.nih.gov/pubmed/30153385

Genotype-Phenotype Relations for the Parkinson’s Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review

Kasten M, Hartmann C, Hampf J, Schaake S, Westenberger A, Vollstedt EJ, Balck A, Domingo A, Vulinovic F, Dulovic M, Zorn I, Madoev H, Zehnle H, Lembeck CM, Schawe L, Reginold J, Huang J, König IR, Bertram L, Marras C, Lohmann K, Lill CM, Klein C. Mov Disord. 2018 May;33(5):730-741. doi: 10.1002/mds.27352. Epub 2018 Apr 11. https://www.ncbi.nlm.nih.gov/pubmed/29644727