
Publications
Utility and implications of exome sequencing in early-onset Parkinson’s disease
Trinh J, Lohmann K, Baumann H, Balck A, Borsche M, Brüggemann N, Dure L, Dean M, Volkmann J, Tunc S, Prasuhn J, Pawlack H, Imhoff S, Lill CM, Kasten M, Bauer P, Rolfs A,; International Parkinson's Disease Genomics Consortium (IPDGC), Klein C. Mov Disord. 2019 Jan;34(1):133-137. doi: 10.1002/mds.27559. Epub 2018 Dec 10. https://www.ncbi.nlm.nih.gov/pubmed/30537300
Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism
Brüggemann N, Domingo A, Rasche D, Moll CKE, Rosales RL, Jamora RDG, Hanssen H, Münchau A, Graf J, Weissbach A, Tadic V, Diesta CC, Volkmann J, Kühn A0, Münte TF, Tronnier V, Klein C. JAMA Neurol. 2018 Dec 3. doi: 10.1001/jamaneurol.2018.3777. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30508028
Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants.
Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Madoev H, Park JS, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A. Hum Mutat. 2018 Dec;39(12):1901-1915. doi: 10.1002/humu.23602. Epub 2018 Sep 7. https://www.ncbi.nlm.nih.gov/pubmed/30079973
Genotype-phenotype relations for the Parkinson’s disease genes SNCA, LRRK2, VPS35: MDSGene systematic review
Trinh J, Zeldenrust FMJ, Huang J, Kasten M,, Schaake S, Petkovic S, Madoev H, Grünewald A, Almuammar S, König IR, Lill CM, Lohmann K, Klein C, Marras C. Mov Disord. 2018 Dec;33(12):1857-1870. doi: 10.1002/mds.27527. Epub 2018 Oct 24. https://www.ncbi.nlm.nih.gov/pubmed/30357936
Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia
Ohlei O, Dobricic V, Lohmann K, Klein C, Lill CM, Bertram L. Parkinsonism Relat Disord. 2018 Dec;57:50-57. doi: 10.1016/j.parkreldis.2018.07.018. Epub 2018 Jul 27. https://www.ncbi.nlm.nih.gov/pubmed/30100364
The revival of the Gini importance?
Nembrini S, König IR, Wright MN. Bioinformatics. 2018 Nov 1;34(21):3711-3718. doi: 10.1093/bioinformatics/bty373. https://www.ncbi.nlm.nih.gov/pubmed/29757357
PINK1-dependent mitophagy is driven by the UPS and can occur independently of LC3 conversion
Rakovic A, Ziegler J, Mårtensson CU, Prasuhn J, Shurkewitsch K, König P, Paulson HL, Klein C. Cell Death Differ. 2018 Oct 30. doi: 10.1038/s41418-018-0219-z. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/30375512
Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
Seibler P, Burbulla LF, Dulovic M, Zittel S,, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C. Brain. 2018 Oct 1;141(10):3052-3064. doi: 10.1093/brain/awy230. https://www.ncbi.nlm.nih.gov/pubmed/30169597
Generation and characterization of eight human-derived iPSC lines from affected and unaffected THAP1 mutation carriers
Baumann H, Jahn M, Muenchau A, Trilck-Winkler M, Lohmann K, Seibler P. Stem Cell Res. 2018 Dec;33:60-64. doi: 10.1016/j.scr.2018.09.018. Epub 2018 Oct 1. https://www.ncbi.nlm.nih.gov/pubmed/30316041
Basal ganglia and cerebellar pathology in X-linked dystonia-parkinsonism
Hanssen H,, Heldmann M, Prasuhn J,, Tronnier V, Rasche D, Diesta CC, Domingo A, Rosales RL, Jamora RD, Klein C, Münte TF, Brüggemann N. Brain. 2018 Oct 1;141(10):2995-3008. doi: 10.1093/brain/awy222. https://www.ncbi.nlm.nih.gov/pubmed/30169601
CONTACT
Institute of Neurogenetics
University of Lübeck
BMF, Building 67
Ratzeburger Allee 160
23538 Lübeck Germany
Phone: +49 451 3101 8230
Fax: +49 451 3101 8204