Publications

New insights into the complex role of mitochondria in Parkinson’s disease

Grünewald A, Kumar KR, Sue CM. Prog Neurobiol 2018; in press.

3D culture of Parkinson’s disease specific dopaminergic neurons for high content phenotyping and drug testing

Bolognin S, Fossepre M, Qing X, Jarazo J, Ščančar J, Lucumi Moreno E, Nickles SL, Wasner K, Ouzren N, Walter J, Grünewald A, Glaab E, Salamanca L, Fleming RMT, Antony P, Schwamborn JC. Adv Sci 2018; in press.

Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism

Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N,  Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. Mov Disord 2018; in press.

Neuroimaging Abnormalities in Individuals Exhibiting Parkinson’s Disease Risk Markers. Mov Disord, in press.

Heldmann M*, Heeren J*, Klein C, Rauch L, Hagenah J, Münte TF, Kasten M, Brüggemann N (2018)

Genotype-phenotype relations for the Parkinson’s Disease genes Parkin, PINK1, DJ1: MDSGene Systematic Review.

Kasten M, Hartmann C, Hampf J, Schaake S, Westenberger A, Vollstedt EJ, Balck A, Domingo A, Vulinovic F, Dulovic M, Zorn I, Madoev H, Zehnle H, Lembeck CM, Schawe L, Reginold J, Huang J, König IR, Bertram L, Marras C, Lohmann K, Lill CM, Klein C. Mov Disord. 2018 Apr 11. doi: 10.1002/mds.27352. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/29644727

Genome-Edited, TH-expressing Neuroblastoma Cells as a Disease Model for Dopamine-Related Disorders: A Proof-of-Concept Study on DJ-1-deficient Parkinsonism

Jannik Prasuhn, Christoph U. Mårtensson, Victor Krajka, Christine Klein,* and Aleksandar Rakovic. Front Cell Neurosci. 2017; 11: 426. Published online 2018 Jan 8. doi:10.3389/fncel.2017.00426. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770810/

Reduced penetrance of Leucine-rich repeat kinase 2 mutations: Discovering genetic factors of endogenous disease protection

Balck A, Klein C. Mov Disord. 2017 Apr;32(4):527. doi: 10.1002/mds.26940. Epub 2017 Feb 20. https://www.ncbi.nlm.nih.gov/pubmed/28218415

DNAJC12 and dopa-responsive nonprogressive parkinsonism

Straniero L, Guella I, Cilia R, Parkkinen L, Rimoldi V, Young A, Asselta R, Soldà G, Sossi V, Stoessl AJ, Priori A, Nishioka K, Hattori N, Follett J, Rajput A, Blau N, Pezzoli G, Farrer MJ, Goldwurm S, Rajput AH, Duga S. Ann Neurol. 2017 Oct;82(4):640-646. doi: 10.1002/ana.25048. Epub 2017 Oct 11. https://www.ncbi.nlm.nih.gov/pubmed/28892570

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Volta M, Beccano-Kelly DA, Paschall SA, Cataldi S, MacIsaac SE, Kuhlmann N, Kadgien CA, Tatarnikov I, Fox J, Khinda J, Mitchell E, Bergeron S, Melrose H, Farrer MJ, Milnerwood AJ. Elife. 2017 Sep 20;6. pii: e28377. doi: 10.7554/eLife.28377. https://www.ncbi.nlm.nih.gov/pubmed/28892570

GCH1 mutations are common in Serbian patients with dystonia-parkinsonism: Challenging previously reported prevalence rates of DOPA-responsive dystonia

Dobričić V, Tomić A, Branković V, Kresojević N, Janković M, Westenberger A, Rašić VM, Klein C, Novaković I, Svetel M, Kostić VS. Parkinsonism Relat Disord. 2017 Dec;45:81-84. doi: 10.1016/j.parkreldis.2017.09.017. Epub 2017 Sep 18. https://www.ncbi.nlm.nih.gov/pubmed/28958832