Christine Klein, MD
Director (Institute of Neurogenetics, Section of Clinical and Molecular Neurogenetics at the Department of Neurology and Interim Director of the Department of Human Genetics), W3 Professor
- University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany
- +49-451-31018200
- +49-451-31018204
- christine.klein@uni-luebeck.de
- https://www.neurogenetics-luebeck.de
1988-1995 Medical School (Hamburg, Heidelberg, Lübeck, London, Oxford)
1991-1992 Medical Thesis (Craig Garner, Center of Molecular Neurobiology, Hamburg
1995-2004 Neurology resident at the Department of Neurology, University of Lübeck
1997-1999 Neurogenetics Research Fellow (Laboratory of Xandra O. Breakefield), Molecular Neurogenetics Unit, Harvard Medical School, Boston, USA
2001 Habilitation (Neurogenetics)
2004 Neurology Board Certification
2004-2015 Fellowships/Sabbaticals with Anthony E. Lang, Toronto, Canada
2005-2009 Lichtenberg Professor of Clinical and Molecular Neurogenetics (W2)
2009-present Schilling Professor of Clinical and Molecular Neurogenetics (W3)
2012 Offer: Head of Neurology, University of Ottawa, Canada (declined)
2012 Offer: James A. Moore Chair in Parkinson’s Disease, University of British Columbia, Vancouver, Canada (declined)
2013-present Director of the Institute of Neurogenetics, Section Head at the Department of Neurology, University of Lübeck
2019-present Interim Director of the Institute of Human Genetics, University of Lübeck
2011-2015 Adviser to the German Government on rare diseases
2012-2016 Member of the DFG Neuroscience Study Section and Emmy Noether Panel
2013-present Associate Editor of Movement Disorders (elected Deputy Editor as of 2020)
2013-2019 Member of the DFG Senate Committee on Key Questions in Clinical Research
2015-2017 Chair of the Congress Scientific Planning Committee of the International Parkinson and Movement Disorder Society, World Congresses 2016, 2017
2015-present Member of the Else Kröner Fresenius Foundation Science Committee
2018-present Member of the DFG Selection Committee for the Heinz Maier-Leibnitz Prize
2019-present President of the German Neurological Society
2002 Winner of the first PhD/MD training award of the University of Duisburg Essen (best poster and best oral presentation)
2007 Travel award of the German Society of Human Genetics
2007 Isabelle Oberlé Award of the European Society of Human Genetics
2011 Travel award of the International Conference for Human Genetics (ICHG, Montral Canada)
2012 Dr. Holger Müller Research Award (Care for Rare Foundation)
2015 Frank Majewski Award
From 450 original publications; total citations: 29,639; h-index: 88
- Pramstaller PP, Schlossmacher MG, Jacques TS, Scaravilli F, Eskelson C, Pepivani I, Hedrich K, Adel S, Gonzales-McNeal M, Hilker R, Kramer PL, Klein C. Lewy body Parkinson disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol 2005;58:411-422. [IF: 7.6]
- Klein C, Lohmann-Hedrich K, Rogaeva E, Schlossmacher MG, Lang AE. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662. [IF: 10.2]
- Morais VA, Haddad D, Craessaerts K, De Bock P-J, Swerts J, Vilain S, Aerts L, Overbergh L, Gruenewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss of function mutations affect Complex I activitz via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207. [IF: 33.6]
- Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acun P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Müller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Cell 2018;172:897-909. [IF:36.2]
- Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Mov Disord 2018;33:1108-1118. [IF:8.3]
- Kasten M, Hartmann C, Hampf J, Schaake S, Westenberger A, Vollstedt EJ, Balck A, Domingo A, Vulinovic F, Dulovic M, Zorn I, Madoev H, Zehnle H, Lembeck CM, Schawe L, Reginold J, Huang J, König IR, Bertram L, Marras L, Lohmann K, Lill CM, Klein C, Rakovic A, Ziegler J, Martensson CU, Prasuhn J, Shurkewitsch K, Koenig P, Paulson HL, Klein C. Genotype-Phenotype Relations for the Parkinson’s Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review. Mov Disord 2018;33:730-741. [IF:8.3]
- Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-1 induced inflammation. Nature 2018;561:258-262. [IF:41.6]
- Brüggemann N, Domingo A, Rasche D, Moll CK, Rosales RL, Jamora RDG, Hanßen H, Münchau A, Graf J, Weißbach A, Tadic V, Diesta CD, Volkmann J, Kühn A, Münte TF, Tronnier V, Klein C. Short- and long-term effects of pallidal neurostimulation and outcome 1 predictors in X-linked dystonia-parkinsonism. JAMA Neurol 2018;76:211-216. [IF:12.3]
- Westenberger A, Reyes C, Saranza G, Dobričić V, Hanßen H, Domingo A, Laabs B-H, Schaake S, Pozojevic J, Rakovic A, Gruetz K, Begemann K, Walter U, Dressler D, Bauer P, Rolfs A, Münchau A, Kasier F, Ozelius L, Jamora RD, Rosales R, Diesta C, Lohmann K, König I, Brüggemann N, Klein C. A hexanucleotide repeat modifies expressivity of X-linked dystonia-parkinsonism. Ann Neurol 2019;85:812-822. [IF:9.5]
- Vollstedt EJ, Kasten M, Klein C, MJFF Global Genetic Parkinson’s Disease Study Group. Using global team science to identify genetic Parkinson’s disease worldwide. Ann Neurol 2019;86:153-157. [IF:9.5]