Anne Grünewald, PhD
Research Group Leader (Institute of Neurogenetics), PhD
- University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Lux.
- +352-46-66 44 9793
- +49-451-2903355
- anne.gruenewald@uni.lu
- https://wwwen.uni.lu/lcsb
- University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
- +49-451-31018201
- +49-451-31018204
2003 German Academy Exchange Service (DAAD) Fellow, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France
2004-2005 Graduate Engineer Diploma in Biotechnology, European Neuroscience Institute (Laboratory of Prof S. Sigrist), University of Göttingen, Germany
2005-2008 PhD Thesis, Section of Clinical & Molecular Neurogenetics (Head: Prof. C. Klein), University of Lübeck, Germany
2006 Visiting Scientist, Department of Clinical Genetics (Laboratory of Prof. V. Bonifati), Erasmus University Medical Center, Rotterdam, The Netherlands
2007-2008 DAAD Fellow, Department of Clinical Neurosciences (Head: Prof. A.H.V. Schapira), University College London, UK
2009-2012 Research Associate and Head, Mitochondrial Function in Movement Disorders Junior Group, Institute of Neurogenetics, University of Lübeck, Germany
2010 Visiting Scientist, Kolling Institute of Medical Research (Laboratory of Prof. C. Sue), University of Sydney, Australia
2012-2015 German Research Foundation (DFG) Fellow and Research Associate, Wellcome Trust Centre for Mitochondrial Research (Head: Prof. D. Turnbull), Newcastle University, UK
2016-present Ass. Professor, National Research Fund Luxembourg (FNR) ATTRACT Fellow, Head of the Molecular and Functional Neurobiology Research Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg
2018-present Ass. Professor (“Brückenprofessor”, W2 level), Head of the Mitochondrial Function in Movement Disorders Section, Institute of Neurogenetics, University of Lübeck, Germany
2017-present Steering Committee member of the Uni. of Lux. Leadership Academy
2018-present Scientific Advisory Board member for the H2020 SysMedPD consortium
2018-present Member of the University Council at the University of Luxembourg
2019-present Member of the Gender Equality Committee at the University of Luxembourg
2010-2014 Research Award from the DFG
2011-2012 Research Award from the Dystonia Medical Research Foundation
2012-2014 Research Award from the Fritz Thyssen Foundation
2012-2013 International Research Fellowship from the DFG
2016-2021 FNR ATTRACT Career Development Grant
2017-2021 PI in DFG/FNR-funded Research Unit
2017-2021 PI in two FNR Doctoral Training Units
2018-2010 Co-PI in FNR CORE Grant
2018-2020 PI in Michael J. Fox Foundation-funded project
2019-2023 PI in FNR-funded National Centre of Excellence in Research
2020-2023 PI in FNR CORE Grant
- Grünewald A, Kasten M, Ziegler A, Klein C. Next generation phenotyping using the Parkin example: Time to catch up with genetics. JAMA Neurol 2013; 70:1186-91. [IF: 7.6]
- Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science 2014;344:203-207. [IF: 33.6]
- Grünewald A, Arns B, Meier B, Brockmann K, Tadic V, Klein C. Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated PD? Antioxid Redox Signal 2014;20:1955-1960. [IF: 7.4]
- Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 2015;16:33-38. [IF: 22.3]
- Grünewald A, Rygiel KA, Hepplewhite PD, Morris CM, Picard M, Turnbull DM. Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Ann Neurol 2016; 79:366-78. [IF: 10.0]
- Grütz K, Seibler P, Weissbach A, Lohmann K, Carlisle FA, Blake DJ, Westenberger A, Klein C, Grünewald A. Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Sci Rep 2017;7:41156. [IF: 5.6]
- Bolognin S, Fossepre M, Qing X, Jarazo J, Ščančar J, Lucumi Moreno E, Nickles SL, Wasner K, Ouzren N, Walter J, Grünewald A, Glaab E, Salamanca L, Fleming RMT, Antony P, Schwamborn JC. 3D culture of Parkinson’s disease specific dopaminergic neurons for high content phenotyping and drug testing. Adv Sci 2018; 20;6:1800927. [IF: 12.4]
- Grünewald A, Kumar KR, Sue CM. New insights into the complex role of mitochondria in Parkinson’s disease. Prog Neurobiol 2019; 177:73-93. [IF: 14.2]
- Ouzren N, Delcambre S, Ghelfi J, Seibler P, Farrer MJ, Aasly JO, Trinh J, Klein C, Grünewald A. MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Ann Neurol 2019; 86:324-326. [IF: 9.5]
- Grossmann D, Scheibner D, Bellet ME, Bohler J, Rapaport D, Berenguer C, Massart F, Skupin A, Fouquier d’Herouël A, Sharma M, Lichtner P, Antony P, Glaab E, May P, Dimmer KS, Fitzgerald JC, Grünewald A (shared senior author), Krüger R. Rare variants in RhoT1/Miro1 impair mitochondrial and calcium homeostasis in Parkinson’s disease. Antioxid Redox Signal 2019; in press. [IF: 5.8]