JOANNE TRINH

 

PERSONAL INFORMATION

Position/Title: Research Group Leader (Institute of Neurogenetics)

Address: Institute of Neurogenetics, University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49 (0)451 3101 8230 ; Fax: +49 (0)451 3101-8204

@: joanne.trinh@neuro.uni-luebeck.de; www.neurogenetics-luebeck.de

 

EDUCATION/POSITIONS

2008-2012 Bachelor of Science (University of British Columbia, Vancouver, Canada)

2012-2017 PhD Thesis (Centre for Applied Neurogenetics, Department of Medical Genetics, University of British Columbia)

2015-2016 Visiting Scientist (VIB Department of Molecular Genetics, University of Antwerp)

2017-2018 Postdoctoral research (Institute of Neurogenetics, University of Lübeck)

2018-present Leader of research group “Integrative Omics approaches in Parkinson’s disease” (Institute of Neurogenetics, University of Lübeck) 

2020 Habilitation (Assistant Professor equivalent) Medicine at University of Lübeck

 

ACADEMIC ACTIVITIES

2010-present Member of the American Society of Human Genetics

2012-present Member of the Michael J. Fox Foundation LRRK2 modifier consortium

2013-present Member of the Michael J. Fox Foundation LRRK2 consortium

2012-present Ad Hoc Reviewer (Journals): Nature Communications, Nature Neurology Reviews, Annals of Neurology, Movement Disorders, European Journal of Neurology, Scientific Reports, Neuroscience Letters, Parkinsonism and Related Disorders, Frontiers of Neurology, Journal of Neurological Sciences, Neurobiology of Aging, Parkinson’s disease

2019-present Review Editor, Frontiers of Neurology – Neurogenetics; Review Editor, Frontiers of Neurology – Movement Disorders; Topic Editor, Genes

AWARDS

2010-present International and National Travel Awards: >10 (e.g. MDS International Congress Travel Award, Colorado Keystone Meeting Travel Award, GeoPD Travel Award, Cold Spring Harbor Travel Award)

2010-present Poster Awards: 1st place (Life Sciences Institute, UBC), Honourable Mention (National Canadian Institutes of Health Research), Honourable Mention (CCMT/CFRI UBC Competition), Best Poster (NGS Symposium, Cancer Agency)

2014 UBC Four Year Fellowship Award and Tuition Award

2014 Simons Foundation Doctoral Award

2014 Canadian Institutes of Health Research Doctoral Award

2015 Michael Smith Foreign Exchange Supplement Award (CIHR)

2015 James Miller Memorial Award for Outstanding Translational Research (Department of Medical Genetics, UBC)

2015 Faculty of Medicine Graduate Student Award

2017 Alexander Von Humboldt Postdoctoral Fellowship

2017 CIHR Postdoctoral Fellowship (deferred)

2017 Joachim Herz Stiftung: Add-on Fellowship for Interdisciplinary Science

2019 Peter and Traudl Engelhorn Fellowship

RESEARCH GRANTS AWARDED

Active Grants

“Identification of pathogenic structural variants and repeat expansions in Parkinson’s disease”

Principal Investigator: Dr. Joanne Trinh, Prof. Katja Lohmann, Prof. Hauke Busch

Funding agency: DFG

Funding period: 2021-2024

€459,299

“P1: Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease”

Principal Investigator: Prof. Anne Grunewald, Prof. Meike Kasten, Dr. Joanne Trinh

Funding agency: DFG (Research Unit FOR2488)

Funding period: 2020-2023

€203,704

“Investigation of age-at-onset genetic modifier loci in LRRK2 parkinsonism”

Principal Investigator: Dr. Joanne Trinh

Funding agency: Else Kröner Fresenius Foundation

Funding period: 2020-2023

€267,850

“Deep characterization of mitochondrial DNA to discover penetrance modifiers of monogenic Parkinson’s disease”

Principal Investigator: Dr. Joanne Trinh

Peter and Traudl Engelhorn Grant

Funding agency: Peter Engelhorn Foundation

Funding period: 2020-2021

€155,000

“Mechanism and Markers of Reduced Penetrance in LRRK2 mutation carriers using induced pluripotent stem cells”

Principal Investigator: Dr. Joanne Trinh

Canadian Institutes of Health Research

Funding agency: Canadian Tri-Agency Federal funding

Funding period: 2019-2021 (deferred)

$150,000 CAD

Completed grants

“Integrative omics approaches to investigate the reduced penetrance of Parkinson disease”

Principal Investigator: Dr. Joanne Trinh

Funding agency: University of Lübeck Intramural project funding

Funding period: 2019-2020

€75,000

“Omics approaches in Parkinson disease”

Principal Investigator: Dr. Joanne Trinh

Joachim Herz Stiftung: Add-on Fellowship for Interdisciplinary Science

Funding agency: Joachim Herz Stiftung

Funding period: 2017-2020 (prolonged)

€12,500

“Investigation of LRRK2 modifiers”

Principal Investigator: Dr. Joanne Trinh

Alexander Von Humboldt Fellowship Grant

Funding agency: Humboldt Foundation

Funding period: 2017-2019

€68,600

“Disease penetrance modifiers”

Principal Investigator: Dr. Joanne Trinh

CIHR Michael Smith Foreign Exchange Supplement

Funding agency: Canadian Tri-Agency Federal funding

Funding period: 2015

$6,000 CAD

“Genetic modifiers of disease penetrance of LRRK2 p.Gly2019Ser parkinsonism”

Principal Investigator: Dr. Joanne Trinh

CIHR Doctoral Award – Charles Best Canada Graduate Scholarship

Funding agency: Canadian Tri-Agency Federal funding

Funding period: 2014-2017

$105,000 CAD

“Genetic modifiers of disease penetrance of LRRK2 p.Gly2019Ser parkinsonism”

Principal Investigator: Dr. Joanne Trinh

Simons Foundation Doctoral Scholarship

Funding agency: Simons Foundation

Funding period: 2014

$5,750 CAD

“Investigation of penetrance in parkinsonism”

Principal Investigator: Dr. Joanne Trinh

UBC Four Year Fellowship Recipient and Tuition award (Awarded by title)

Funding agency: University of British Columbia

Funding period: 2014-2017

$88,000 CAD

“Penetrance modifiers in LRRK2”

Principal Investigator: Dr. Joanne Trinh

Leading Edge Endowment Fund Graduate Studentship

Funding agency: Genome BC

Funding period: 2012-2017

$25,000 CAD

EDUCATIONAL ACTIVITIES

Teaching

2021    Third generation sequencing consolidation coure, “Molecular Life Science” Program, University of Lübeck, Germany. Course Coordinator: PD Dr. Joanne Trinh

2020    Neurobiomedicine  “Molecular Life Science” Program,  University of Lübeck, Germany

Course Coordinator: Prof. Philip Seibler

2019    Neurobiomedicine  “Molecular Life Science” Program,  University of Lübeck, Germany

Course Coordinator: Prof. Philip Seibler

2016    Teaching Assistant for Advanced Cell Biology 200W, University of British Columbia, Vancouver, BC. Course Coordinator: Dr. Robin Young

2015    Genetic modifiers of neurological disorders. Medical lecture at Trondheim University. Trondheim, Norway. Invited by Director Prof. Jan Aasly.

2014    Teaching Assistant for Advanced Medical Genetics 420W, University of British Columbia, Vancouver, BC. Course Coordinator: Prof. Carles Vilarino-Guell

Mentorship

Theresa Lüth (PhD student)

Description: Mentor for PhD thesis

Current status: PhD student at Institute of Neurogenetics

Carolin Gabbert (PhD student)

Description: Mentor for PhD thesis

Current status: PhD student at Institute of Neurogenetics

Joshua Lass (MSc student)

Description: Mentor for MLS internship practical studies

Current status: MSc student in MLS studies Luebeck

Beke Kolms (MSc student)

Description: Mentor for MLS internship practical studies

Current status: MSc student in MLS studies Luebeck

Carolin Gabbert (MSc student)

Description: Mentor for Master’s thesis

Result: Graduated with highest distinction

Current status: Scientist employed at Institute of Neurogenetics

Theresa Lüth (MSc student)

Description: Mentor for internship practical studies and Master’s thesis

Result: Graduated with highest distinction

Current status: PhD student at Institute of Neurogenetics

Anna Gramalla (MSc student)

Description: Mentor for internship practical studies

Current status: PhD student in Switzerland

Elisabeth Luisa Germer (MD student)

Description: Mentor for doctoral thesis on mapping novel recessive genes for Parkinson’s disease

Current status: Medical student at the University of Luebeck

Sophie Imhoff (MD student)

Description: Mentor for doctoral thesis on mitochondrial disorders and deep mitochondrial sequencing

Current status: Thesis under review, medical student at the University of Luebeck

Miguel Ramirez (PhD student)

Description: Mentor for exome sequencing in familial PD

Current status: PhD student at the University of British Columbia

Ben Chen (BSc student)

Description: Mentor for Summer student on exome sequencing in PD

Current status: completed BSc at the University of British Columbia

Mary Encarnacion (BSc student)

Description: Mentor for Summer studentship (Co-operative education program)

Current status: Research Technologist

Mimi Wei (BSc student)

Description: Supervisor for undergraduate research experience

Current status: completed BSc at the University of British Columbia

Shannon Tang (BSc student)

Description: Supervisor for undergraduate research experience

Current status: completed BSc at the University of British Columbia

Katheline Cao (BSc student)

Description: Supervisor for undergraduate research experience

Current status: completed BSc at the University of British Columbia

Aditi Chadha (BSc student)

Description: Supervisor for undergraduate research experience

Current status: completed BSc at the University of British Columbia

INVITED LECTURES AND ORAL PRESENTATIONS

Genotype-Phenotype Correlations. International Movement Disorders Society Congress. Invited Lecture. Philadelphia, USA. 2020 Sept 15. (moved to virtual conference due to Covid-19)

70th Annual Lindau Nobel Laureate Meeting. Lindau, Germany. 2021 June 27 – July 2 (cancelled and moved due to Covid-19).

Genetics modifiers of Parkinson’s disease. Seminar at the Joachim Herz Stiftung. Annual Meeting. Hamburg, Germany. 2019 Sept 21.

Using analytics in the context of genetics and neurological diseases. Invited Talk. Hexal Symposium. Interdisciplinary modern analytics. Holzkirchen, Munich. 2019 July 22.

Genetics and penetrance modifiers in neurological disease. Seminar at the Helmholtz Zentrum, Munich. Invited by Professor Juliane Winkelmann. 2019 July 25.

From Phenotype to Genotype and Back: The MDSGene Database. Invited Talk. International Parkinson’s Disease Genetics Consortium. Lisbon, Portugal 2019 March 24.

De-novo TAOK1 mutations in neurodevelopmental disorders. Selected Platform. German Society of Human Genetics. Weimar, Germany. 2019 February 27.

Reduced penetrance of parkinsonism. Selected Talk. Alexander Von Humboldt  Fellowship Meeting lecture. Potsdam, Germany. 2018 February 21.

MDSGene database skills workshop lecture. Invited Seminar. International Movement Disorders Society Congress. Vancouver, BC, Canada. 2017 June 7.

Reduced penetrance of LRRK2 parkinsonism. Invited Seminar at the DPG Congress. Baden-Baden, Germany. 2017 May 5.

Genetic modifiers of LRRK2 parkinsonism. Seminar at the VIB. Antwerp, Belgium. Invited by Professor Christine Van Broeckhoven. 2016 January 13

Genetic modifiers of LRRK2 parkinsonism. Seminar at Karolinska Institute. Stockholme, Sweden. Invited by Professor Caroline Graff. 2016 January 19

Genetic modifiers of LRRK2 parkinsonism. Seminar at the University of Luebeck Institute of Neurogenetics. Luebeck, Germany. Invited by Professor Christine Klein. 2015 December 3

Genetic modifiers of neurological disorders. Medical lecture at Trondheim University. Trondheim, Norway. Invited by Director Jan Aasly. 2015 October 19

DNM3; a genetic modifier of LRRK2 parkinsonism. Platform Presentation at 2014 Annual Meeting Genetic Epidemiology of Parkinson disease. September 10-12, Vancouver, BC.

 

SELECTED PUBLICATIONS

From 43 publications; total citations: >1,900; h-index: 16, i-index: 22

  1. Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, Volta M, Beccano-Kelly D, Thompson C, Lin MK, Sherman HE, Han HJ, Guenther BL, Wasserman WW, Bernard V, Ross CJ, Appel-Cresswell S, Stoessl AJ, Robinson CA, Dickson DW, Ross OA, Wszolek ZK, Aasly JO, Wu RM, Hentati F, Gibson RA, McPherson PS, Girard M, Rajput M, Rajput AH, Farrer MJ. DNAJC13 mutations in Parkinson disease. Human Molecular Genetics. 2014;23(7):1794-801. (IF: 39)
  2. Trinh J, Amouri R, Duda JE, Morley JF, Read M, Donald A, Vilariño-Güell C, Thompson C, Szu Tu C, Gustavsson EK, Sassi SB, Hentati E, Zouari M, Farhat E, Nabli F, Hentati F, Farrer MJ. A comparative study of Parkinson;s disease and LRRK2 p.G2019S parkinsonism. Neurobiology of Aging. 2014;35(5):1125-31 (IF: 85).
  3. Hentati F, Trinh J (equally contributing first author), Thompson C, Nosova E, Farrer M, Aasly J. LRRK2 parkinsonism in Tunisia and Norway: A comparative study of disease penetrance. Neurology. 2014; 83(6):568-9. (IF: 286)
  4. Trinh J, Guella I, Farrer M. Disease penetrance of late-onset parkinsonism: a meta-analyses. JAMA 2014;71(12):1535-9. (IF: 7.271)
  5. Trinh J, Gustavsson EK, Vilariño-Güell C, Latourelle J, McKenzie M, Szu Tu C, Nosova E, Khina J, Lesage S, Brice A, Aasly J, Parkkinen L, Foroud T, Myers RH, Milnerwood A, Sassi SB, Hentati E, Nabli F, Farhat E, Amouri R, Hentati F, Farrer MJ. DNM3 modifiers age of onset in LRRK2 parkinsonism: a linkage and association study. Lancet 2016;15(12):1248-1256. (IF: 26.28)
  6. Trinh J, Lohmann K (equally contributing first author), Baumann H, Balck A, Borsche M, Brüggemann N, Dure L, Tünc S, Prasuhn J, Pawlack H, Imhoff S, Lill CM, Kasten M, Bauer P, Rolfs A, Klein C. Utility and implications of exome sequencing in early-onset Parkinson’s disease. Movement Disorders. 2019;34(1):133-137. (IF: 061)
  7. Trinh J, Zeldenrust FMJ, Huang Jana, Kasten M, Petkovic S, Madoev H, Zorn I, Schaake S, König I, Bertram L, Lohmann K, Lill CM, Klein C, Marras C. Genotype-phenotype relations for the Parkinson’s disease genes: SNCA, LRRK2, VPS35: MDSGene systematic review. Movement Disorders. 2018;33(12):1857-1870. (IF: 061)
  8. Kia DA, Sabir MS, Ahmed S, Trinh J, Badres-Ciga S. Analysis of LRP10 in a large series of Parkinson’s disease. Lancet 2018; 17(12):1032. (IF: 28.755)
  9. Dulovic Mahlow M, Trinh J (equally contributing first author), Kandaswamy KK, Braathen GJ, Werber M, Krajka V, Busk OL, Oprea G, DiDonato N, Vos M, Rolfs A, Lohmann K. De-novo mutations in TAOK1 cause neurodevelopmental disorders. American Journal of Human Genetics. 2019; 105(1):213-220. (IF: 9.924)
  10. Lüth F, König I, Grünewald A, Kasten M, Klein C, Hentati F, Farrer M, Trinh J. Age at onset of LRRK2 p.Gly2019Ser is related to environmental and lifestyle factors. Movement Disorders. 2020. doi:10.1002/mds.28238 2020 (IF: 8.76)