Position/Title: Research Group Leader (Institute of Neurogenetics), PhD

W2 Professor

Address University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-2903352; Fax: +49-451-2903355




2001-2006 Studies of Molecular Life Sciences (University of Lübeck)

2006 Master Thesis (Prof. Christine Klein, Institute of Neurogenetics)

2006-2011 PhD Studies (Prof. Christine Klein, Institute of Neurogenetics)

2011 PhD Thesis: summa cum laude

2009-2010 Fellowship with Prof. Dimitri Krainc (MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Boston, USA)

2011 Postdoctoral researcher at the Institute of Neurogenetics, University of Lübeck

2013 Research group leader “Human Neurons Derived from Induced Pluripotent Stem Cells” at the Institute of Neurogenetics, University of Lübeck



2009 DAAD one-year graduate student fellowship, Harvard Medical School, USA

2011 Young Investigator Award of the German Society of Neurogenetics

2015 International Research Fellowship from the DFG, University of British Columbia, Canada



From 16 original publications; total citations: 571; h-index: 10

    1. Seibler P, Djarmati A, Langpap B, …, Klein C. A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient. Lancet Neurol 2008;7:380-381. (IF: 14.3)
    1. Rakovic A, Grünewald A, Seibler P, …, Klein C. Effect of endogenous mutant and wild-type PINK1 on
      Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137. (IF: 8.1)
    1. Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells. J Neurosci
      2011;31:5970-5976. (IF: 7.1)
    1. Rakovic A, Shurkewitsch K, Seibler P, …, Klein C. Phosphatase and tensin homolog (PTEN)-induced
      putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J Biol Chem 2013;288:2223-2237. (IF: 4.6)
    1. Trilck M, Hübner R, Seibler P, Klein C, Rolfs A, Frech MJ. Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks. Orphanet J Rare Dis 2013;8:144. (IF: 4.0)
    1. Doss S, Lohmann K, Seibler P, …, Klein C. Recessive dystonia-ataxia syndrome in a Turkish family
      caused by a COX20 (FAM36A) mutation. J Neurol 2014;261:207-212. (IF: 3.4)
    1. Morais VA, Haddad D, Craessaerts K, …, Seibler P, …, De Strooper B. PINK1 loss of function mutations
      affect Complex I activity via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207. (IF: 33.6)
    1. Vulinovic F, Lohmann K, Rakovic A, …, Seibler P. Unraveling cellular phenotypes of novel
      TorsinA/TOR1A mutations. Hum Mutat 2014;35:1114-1122. (IF: 5.1)
    1. Munsie LN, Milnerwood AJ, Seibler P (equally contributing first author), …, Farrer MJ. Retromer-
      dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson’s Disease VPS35
      mutation p.D620N. Hum Mol Genet 2015;24:1691-703. (IF: 6.4)
    1. Rakovic A, Seibler P, Klein C. iPS models of Parkin and PINK1. Biochem Soc T 2015;43:302-307. (IF: