MICHAELA TRILCK-WINKLER

 

PERSONAL INFORMATION

Position/Title: Head of Laboratory and Postdoctoral Researcher (Section Applied Stem Cell Biology)
Project Coordinator of the Research Unit FOR2488 “Protect Move”

Address University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-31018203; Fax: +49-451-31018204

@: michaela.trilck@neuro.uni-luebeck.de; www.neurogenetics-luebeck.de

 

EDUCATION/POSITIONS

2005-2010 Studies of Medical Biotechnology (University of Rostock)

2008 Bachelor Thesis (Prof. Bernd Kreikemeyer, Institute for Medical Microbiology, Virology and Hygiene, Rostock)

2010 Master Thesis (Prof. Arndt Rolfs, Albrecht Kossel-Institute for Neuroregeneration, Rostock)

2010-2014 PhD Studies (Prof. Arndt Rolfs, Albrecht Kossel-Institute for Neuroregeneration, Rostock)

2014 PhD Thesis: summa cum laude

2014-2015 Postdoctoral researcher at the Albrecht Kossel-Institute for Neuroregeneration, Rostock

2015-present Postdoctoral researcher at the Institute of Neurogenetics, University of Luebeck

2016-present Project Coordinator of the Research Unit FOR2488 “Protect Move”

2018-present Laboratory Head Section “Applied Stem Cell Biology”

 

ACADEMIC ACTIVITIES

2013 Participant in the DAAD RISE scholarship program (supervision)

AWARDS

2015 Career Development Grant FORUN from Rostock University Medical Center

2017-2018 Career Development Grant FuL from Medical Faculty of the University of Luebeck

ADVANCED TRAINING

2010 Workshop Pluripotent Stem Cells (ESHRE)

2011 FELASA B (compact course laboratory animals, animal testing and alternative methods)

2015 Quality Management Basics I (DGQ)

 

SELECTED PUBLICATIONS

  1. Trilck M, Hübner R, Seibler P, Klein C, Rolfs A, Frech MJ. Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks. Orphanet J Rare Dis. 2013;8:144.
  2. Mußmann C, Hübner R, Trilck M, Rolfs A, Frech MJ. HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. Stem Cells Dev. 2014;23(12):1328-39.
  3. Trilck M, Hübner R, Frech MJ. Generation and Neuronal Differentiation of Patient-Specific Induced Pluripotent Stem Cells Derived from Niemann-Pick Type C1 Fibroblasts. Methods Mol Biol. 2016;1353:233-59.
  4. Trilck M, Peter F, Zheng C, Frank M, Dobrenis K, Mascher H, Rolfs A, Frech MJ. Diversity of Glycosphingolipid GM2 and Cholesterol Accumulation in NPC1 Patient-Specific iPSC-Derived Neurons. Brain Res. 2017 Feb 15; 1657: 52-61. [Epub 2016 Dec 5]
  5. Peter F*, Trilck M*, Rabenstein M, Rolfs A, Frech MJ. Dataset in support of the generation of Niemann-Pick disease Type C1 patient-specific iPS cell lines carrying the novel NPC1 mutation c.1180T>C or the prevalent c.3182T>C mutation – Analysis of pluripotency and neuronal differentiation. Data Brief. 2017 Apr 2; 12: 123-131.
  6. Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I, Seibler P3. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet. 2017 Jul 1;26(13):2412-2425. doi: 10.1093/hmg/ddx132.
  7. Rabenstein M, Peter F, Joost S, Trilck M, Rolfs A, Frech MJ. Decreased calcium flux in Niemann-Pick type C1 patient-specific iPSC-derived neurons due to higher amount of calcium-impermeable AMPA receptors. Mol Cell Neurosci. 2017 Jun 27;83:27-36. doi: 10.1016/j.mcn.2017.06.007. Epub 2017 Jun 27.
  8. Trillhaase A, Haferkamp U, Rangnau A, Märtens M, Schmidt B, Trilck M, Seibler P, Aherrahrou R, Erdmann J, Aherrahrou Z. Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells. Stem Cell Res. 2018 Jul 17;31:62-70. doi: 10.1016/j.scr.2018.07.008.
  9. Baumann H; Jahn M; Münchau A; Trilck-Winkler M*; Lohmann K*; Seibler P*. Generation and characterization of eight human-derived iPSC lines from affected and unaffected THAP1 mutation carriers. Stem Cell Res [under review]