CHRISTINE KLEIN

 

PERSONAL INFORMATION

Position/Title Head: Director (Institute of Neurogenetics, Section of Clinical and Molecular Neurogenetics at the Department of Neurology and Interim Director of the Department of Human Genetics), W3 Professor

Address: University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-31018200; Fax:+49-451-31018204

@: christine.klein@neuro.uni-luebeck.de; www.neurogenetics-luebeck.de

EDUCATION/POSITIONS

1988-1995 Medical School (Hamburg, Heidelberg, Lübeck, London, Oxford)

1991-1992 Medical Thesis (Craig Garner, Center of Molecular Neurobiology, Hamburg

1995-2004 Neurology resident at the Department of Neurology, University of Lübeck

1997-1999 Neurogenetics Research Fellow (Laboratory of Xandra O. Breakefield), Molecular Neurogenetics Unit, Harvard Medical School, Boston, USA

2001 Habilitation (Neurogenetics)

2004 Neurology Board Certification

2004-2015 Fellowships/Sabbaticals with Anthony E. Lang, Toronto, Canada

2005-2009 Lichtenberg Professor of Clinical and Molecular Neurogenetics (W2)

2009-present Schilling Professor of Clinical and Molecular Neurogenetics (W3)

2012 Offer: Head of Neurology, University of Ottawa, Canada (declined)

2012 Offer: James A. Moore Chair in Parkinson’s Disease, University of British Columbia, Vancouver, Canada (declined)

2013-present Director of the Institute of Neurogenetics, Section Head at the Department of Neurology, University of Lübeck

2019-present Interim Director of the Institute of Human Genetics, University of Lübeck

ACADEMIC ACTIVITIES

2011-2015 Adviser to the German Government on rare diseases

2012-2016 Member of the DFG Neuroscience Study Section and Emmy Noether Panel

2013-present Associate Editor of Movement Disorders (elected Deputy Editor as of 2020)

2013-2019 Member of the DFG Senate Committee on Key Questions in Clinical Research

2015-2017 Chair of the Congress Scientific Planning Committee of the International Parkinson and Movement Disorder Society, World Congresses 2016,
2017

2015-present Member of the Else Kröner Fresenius Foundation Science Committee

2018-present Member of the DFG Selection Committee for the Heinz Maier-Leibnitz Prize

2019-present President of the German Neurological Society

AWARDS

1989-1995 German National Merit Foundation (Studienstiftung des deutschen Volkes)

1997-1999 International Research Scholarship from the DFG

2003-2005 Heisenberg Scholarship from the DFG

2005-2009 Lichtenberg Career Development Award from the Volkswagen Foundation

2007 Heinrich Pette Award of the German Neurological Society

2008 Derek-Denny Brown Award of the American Neurological Association

2009-2019 Career Development Award, Hermann and Lilly Schilling Foundation

2011 Julius Brendel Visiting Professor, University of Auckland, New Zealand

2015 Druker Lectureship, Harvard Medical School, Boston, USA

2019 Presidential C. David Marsden Lecture at the International Congress of the Parkinson and Movement Disorder Society (Topic: Reduced Penetrance)

SELECTED PUBLICATIONS

From 450 original publications; total citations: 29,639; h-index: 88

  1. Pramstaller PP, Schlossmacher MG, Jacques TS, Scaravilli F, Eskelson C, Pepivani I, Hedrich K, Adel S, Gonzales-McNeal M, Hilker R, Kramer PL, Klein C. Lewy body Parkinson disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol 2005;58:411-422. [IF: 7.6]
  2. Klein C, Lohmann-Hedrich K, Rogaeva E, Schlossmacher MG, Lang AE. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662. [IF: 10.2]
  3. Morais VA, Haddad D, Craessaerts K, De Bock P-J, Swerts J, Vilain S, Aerts L, Overbergh L, Gruenewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss of function mutations affect Complex I activitz via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207. [IF: 33.6]
  4. Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acun P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Müller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Cell 2018;172:897-909. [IF:36.2]
  5. Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Mov Disord 2018;33:1108-1118. [IF:8.3]
  6. Kasten M, Hartmann C, Hampf J, Schaake S, Westenberger A, Vollstedt EJ, Balck A, Domingo A, Vulinovic F, Dulovic M, Zorn I, Madoev H, Zehnle H, Lembeck CM, Schawe L, Reginold J, Huang J, König IR, Bertram L, Marras L, Lohmann K, Lill CM, Klein C, Rakovic A, Ziegler J, Martensson CU, Prasuhn J, Shurkewitsch K, Koenig P, Paulson HL, Klein C. Genotype-Phenotype Relations for the Parkinson’s Disease Genes Parkin, PINK1, DJ1: MDSGene Systematic Review. Mov Disord 2018;33:730-741. [IF:8.3]
  7. Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-1 induced inflammation. Nature 2018;561:258-262. [IF:41.6]
  8. Brüggemann N, Domingo A, Rasche D, Moll CK, Rosales RL, Jamora RDG, Hanßen H, Münchau A, Graf J, Weißbach A, Tadic V, Diesta CD, Volkmann J, Kühn A, Münte TF, Tronnier V, Klein C. Short- and long-term effects of pallidal neurostimulation and outcome 1 predictors in X-linked dystonia-parkinsonism. JAMA Neurol 2018;76:211-216. [IF:12.3]
  9. Westenberger A, Reyes C, Saranza G, Dobričić V, Hanßen H, Domingo A, Laabs B-H, Schaake S, Pozojevic J, Rakovic A, Gruetz K, Begemann K, Walter U, Dressler D, Bauer P, Rolfs A, Münchau A, Kasier F, Ozelius L, Jamora RD, Rosales R, Diesta C, Lohmann K, König I, Brüggemann N, Klein C. A hexanucleotide repeat modifies expressivity of X-linked dystonia-parkinsonism. Ann Neurol 2019;85:812-822. [IF:9.5]
  10. Vollstedt EJ, Kasten M, Klein C, MJFF Global Genetic Parkinson’s Disease Study Group. Using global team science to identify genetic Parkinson’s disease worldwide. Ann Neurol 2019;86:153-157. [IF:9.5]