CHRISTINE KLEIN

 

PERSONAL INFORMATION

Position/Title Head: (Institute of Neurogenetics), W3 Schilling Professor

Address University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-31018200; Fax:+49-451-31018204

@: christine.klein@neuro.uni-luebeck.de; www.neurogenetics-luebeck.de

EDUCATION/POSITIONS

1988-1995 Medical School (Hamburg, Heidelberg, Lübeck, London, Oxford)

1991-1992 Medical Thesis (Craig Garner, Center of Molecular Neurobiology, Hamburg

1995-2004 Neurology resident at the Department of Neurology, University of Lübeck

1997-1999   Neurogenetics Research Fellow (Laboratory of Xandra O. Breakefield), Molecular Neurogenetics Unit, Harvard Medical School, Boston, USA

2001 Habilitation

2004 Neurology Board Certification

2004-2013 Fellowships/Sabbaticals with Anthony E. Lang, Toronto, Canada

2005-2009 Lichtenberg Professor of Clinical and Molecular Neurogenetics (W2)

2009-present Schilling Professor of Clinical and Molecular Neurogenetics (W3)

2012 Offer: Head of Neurology, University of Ottawa, Canada (declined)

2012 Offer: James A. Moore Chair in Parkinson’s Disease, University of British Columbia, Vancouver, Canada (declined)

2013-present Director of newly founded Institute of Neurogenetics, University of Lübeck

ACADEMIC ACTIVITIES

2003-2012 Editorial Board of Movement Disorders

2008-present Board Member “Gender equality issues at the University of Lübeck”

2008-present Editorial Board of Neurology

2009-present Councilor to the Neurogenetics Section, American Academy of Neurology

2010-2014 Member of the Scientific Advisory Board of the Bachmann-Strauss Dystonia & Parkinson Foundation, USA

2010-present Head of the Neurogenetics Committee of the German Neurological Society

2011-present Adviser to the German Government on rare diseases

2012-present Member of the DFG Neuroscience Study Section

2013-present Associate Editor of Movement Disorders

2015-2017 Chair of the Congress Scientific Planning Committee of the International Parkinson and Movement Disorder Society, World Congresses 2016, 2017

2015-present Member of the Else Krönert Fresenius Foundation Science Committee

AWARDS

1989-1995 German National Merit Foundation (Studienstiftung des deutschen Volkes)

1997-1999 International Research Scholarship from the DFG

2003-2005 Heisenberg Scholarship from the DFG

2005-2009 Lichtenberg Career Development Award from the Volkswagen Foundation

2007 Heinrich Pette Award of the German Neurological Society

2008 Derek-Denny Brown Award of the American Neurological Association

2009-2019 Career Development Award, Hermann and Lilly Schilling Foundation

2011 Julius Brendel Visiting Professor, University of Auckland, New Zealand

2012 Melvin Yahr Lectureship, Mount Sinai Medical Center, New York, USA

2015 Druker Lectureship, Harvard Medical School, Boston, USA

SELECTED PUBLICATIONS

From 365 original publications; total citations: 16,468; h-index: 67

    1. Pramstaller PP, Schlossmacher MG, Jacques TS, …, Klein C. Lewy body Parkinson disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol 2005;58:411-422. (IF: 7.6)
    1. Klein C, Lohmann-Hedrich K, Rogaeva E, Schlossmacher MG, Lang AE. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662. (IF: 10.2)
    1. Healy DG, Falchi M, O’Sullivan SS, …, Klein C, …, International LRRK2 Consortium. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurol 2008;7:583-590. (IF: 14.3)
    1. Rakovic A, Shurkewitsch K, Seibler P, …, Klein C. Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J Biol Chem 2013;288:2223- 2237. (IF: 4.6)
    1. Lohmann K, Wilcox RA, Winkler S, …, Klein C. Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene. Ann Neurol 2013;73:537-545. (IF: 11.9)
    1. Deuse T, Hua X, Wang D, …, Klein C, …, Schrepfer S. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature 2014;509:641-644. (IF: 41.5)
    1. Morais VA, Haddad D, Craessaerts K, …, Klein C. …, De Strooper B. PINK1 loss of function mutations affect Complex I activity via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207. (IF: 33.6)
    1. Grünewald A, Arns B, Meiner B, …, Klein C. Does Uncoupling Protein 2 expression qualify as marker of disease status in LRRK2-associated PD? Antioxid Redox Signal 2014;20:1955-1960. (IF: 7.4)
    1. Munsie LN, Milnerwood AJ, Seibler P, …, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson’s disease VPS35 mutation p. D620N. Hum Mol Genet 2015;24:1691-1703. (IF: 6.4)
    1. Brüggemann N, Kühn A, Schneider SA, …, Klein C. Short-and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia. Neurology 2015;84:895-903. (IF: 8.3)