ANNE GRÜNEWALD

 

PERSONAL INFORMATION

Position/Title: Research Group Leader (Institute of Neurogenetics), PhD

Addresses: University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Lux.

Tel: +352-46-66 44 9793; Fax: +49-451-2903355

@: anne.gruenewald@uni.lu; https://wwwen.uni.lu/lcsb

University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-31018201; Fax: +49-451-31018204

 

EDUCATION/POSITIONS

2003 German Academy Exchange Service (DAAD) Fellow, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France

2004-2005 Graduate Engineer Diploma in Biotechnology, European Neuroscience Institute (Laboratory of Prof S. Sigrist), University of Göttingen, Germany

2005-2008 PhD Thesis, Section of Clinical & Molecular Neurogenetics (Head: Prof. C. Klein), University of Lübeck, Germany

2006 Visiting Scientist, Department of Clinical Genetics (Laboratory of Prof. V. Bonifati), Erasmus University Medical Center, Rotterdam, The Netherlands

2007-2008 DAAD Fellow, Department of Clinical Neurosciences (Head: Prof. A.H.V. Schapira), University College London, UK

2009-2012 Research Associate and Head, Mitochondrial Function in Movement Disorders Junior Group, Institute of Neurogenetics, University of Lübeck, Germany

2010 Visiting Scientist, Kolling Institute of Medical Research (Laboratory of Prof. C. Sue), University of Sydney, Australia

2012-2015 German Research Foundation (DFG) Fellow and Research Associate, Wellcome Trust Centre for Mitochondrial Research (Head: Prof. D. Turnbull), Newcastle University, UK

2016-present Ass. Professor, National Research Fund Luxembourg (FNR) ATTRACT Fellow, Head of the Molecular and Functional Neurobiology Research Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg

2018-present Ass. Professor (“Brückenprofessor”, W2 level), Head of the Mitochondrial Function in Movement Disorders Section, Institute of Neurogenetics, University of Lübeck, Germany

 

ACADEMIC ACTIVITIES

2017-present Steering Committee member of the Uni. of Lux. Leadership Academy

2018-present Scientific Advisory Board member for the H2020 SysMedPD consortium

2018-present Member of the University Council at the University of Luxembourg

2019-present Member of the Gender Equality Committee at the University of Luxembourg

 

AWARDS

2010-2014 Research Award from the DFG

2011-2012 Research Award from the Dystonia Medical Research Foundation

2012-2014 Research Award from the Fritz Thyssen Foundation

2012-2013 International Research Fellowship from the DFG

2016-2021 FNR ATTRACT Career Development Grant

2017-2021 PI in DFG/FNR-funded Research Unit

2017-2021 PI in two FNR Doctoral Training Units

2018-2010 Co-PI in FNR CORE Grant

2018-2020 PI in Michael J. Fox Foundation-funded project

2019-2023 PI in FNR-funded National Centre of Excellence in Research

2020-2023 PI in FNR CORE Grant

SELECTED PUBLICATIONS

From 47 original publications; total citations: 2,300; h-index: 27

    1. Grünewald A, Kasten M, Ziegler A, Klein C. Next generation phenotyping using the Parkin example: Time to catch up with genetics. JAMA Neurol 2013; 70:1186-91. [IF: 7.6]
    2. Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science 2014;344:203-207. [IF: 33.6]
    3. Grünewald A, Arns B, Meier B, Brockmann K, Tadic V, Klein C. Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated PD? Antioxid Redox Signal 2014;20:1955-1960. [IF: 7.4]
    4. Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 2015;16:33-38.
      [IF: 22.3]
    5. Grünewald A, Rygiel KA, Hepplewhite PD, Morris CM, Picard M, Turnbull DM. Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Ann Neurol 2016; 79:366-78. [IF: 10.0]
    6. Grütz K, Seibler P, Weissbach A, Lohmann K, Carlisle FA, Blake DJ, Westenberger A, Klein C, Grünewald A. Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Sci Rep 2017;7:41156. [IF: 5.6]
    7. Bolognin S, Fossepre M, Qing X, Jarazo J, Ščančar J, Lucumi Moreno E, Nickles SL, Wasner K, Ouzren N, Walter J, Grünewald A, Glaab E, Salamanca L, Fleming RMT, Antony P, Schwamborn JC. 3D culture of Parkinson’s disease specific dopaminergic neurons for high content phenotyping and drug testing. Adv Sci 2018; 20;6:1800927. [IF: 12.4]
    8. Grünewald A, Kumar KR, Sue CM. New insights into the complex role of mitochondria in Parkinson’s disease. Prog Neurobiol 2019; 177:73-93. [IF: 14.2]
    9. Ouzren N, Delcambre S, Ghelfi J, Seibler P, Farrer MJ, Aasly JO, Trinh J, Klein C, Grünewald A. MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers. Ann Neurol 2019; 86:324-326.
      [IF: 9.5]
    10. Grossmann D, Scheibner D, Bellet ME, Bohler J, Rapaport D, Berenguer C, Massart F, Skupin A, Fouquier d’Herouël A, Sharma M, Lichtner P, Antony P, Glaab E, May P, Dimmer KS, Fitzgerald JC, Grünewald A (shared senior author), Krüger R. Rare variants in RhoT1/Miro1 impair mitochondrial and calcium homeostasis in Parkinson’s disease. Antioxid Redox Signal 2019; in press. [IF: 5.8]