Position/Title: Research Group Leader (Institute of Neurogenetics), PhD

Address University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-2903352; Fax: +49-451-2903355




2003 DAAD Training Fellow, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France

2004-2005 Graduate Engineer Diploma in Biotechnology, Neuroplasticity Group (Head: Prof. S. Sigrist), European Neuroscience Institute, University of Göttingen, Germany

2005-2008 PhD Thesis, Section of Clinical & Molecular Neurogenetics (Head: Prof. C. Klein), University of Lübeck, Germany

2006 Visiting Scientist, Neurogenetics Group (Head: Prof. V. Bonifati), Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

2007-2008 German Academic Exchange Service (DAAD) Fellow, Department of Clinical Neurosciences (Head: Prof. A.H.V. Schapira), University College London, UK

2009-present Research Associate and Head, Mitochondrial Function in Movement Disorders Junior Group, Institute of Neurogenetics, University of Lübeck, Germany

2010 Visiting Scientist, Neurogenetics Group (Head: Prof. C. Sue), Kolling Institute of Medical Research, University of Sydney, Australia

2012-2014 German Research Foundation (DFG) Fellow, Wellcome Trust Centre for Mitochondrial Research (Head: Prof. D. Turnbull), Newcastle University, UK

2014-2015 Research Associate, Wellcome Trust Centre for Mitochondrial Research (Head: Prof. D. Turnbull), Newcastle University, UK

2016-present Ass. Professor (“Brückenprofessor”, W2 level), Head of the Mitochondrial Function in Movement Disorders Research Group, Institute of Neurogenetics, University of Lübeck, Germany

2016-present Ass. Professor, National Research Fund Luxembourg (FNR) ATTRACT Fellow, Head of the Molecular and Functional Neurobiology Research Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg



2011-present Member of the American Society of Neurology

2012-present Member of the Movement Disorders Society



2010-2011 Research Award from the DFG

2010-2011 Research Award from the Medical Faculty of the University of Lübeck

2011-2012 Research Award from the Dystonia Medical Research Foundation

2011-2013 Career Development Grant from Medical Faculty of the University of Lübeck

2012 DAAD Postdoctoral Fellowship (declined)

2012-2014 Research Award the Fritz Thyssen Foundation

2012-2013 International Research Fellowship from the DFG

2016-2021 FNR ATTRACT Career Development Grant



From 37 original publications; total citations: 1,097; h-index: 19

  1. Grünewald A, Voges L, Rakovic A, …, Klein C. Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One 2010;5:e12962. (IF: 4.4)
  2. Grünewald A, Arns B, Seibler P, …, Klein C. ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiol Aging 2012;33:1843.e1-7. (IF: 6.2)
  3. Wortmann SB, Vaz FM, Gardeitchik T, …, Grünewald A, …, de Brouwer APM. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nat Genet 2012;44:797-802. (IF: 35.2)
  4. Grünewald A, Kasten M, Ziegler A, Klein C. Next generation phenotyping using the Parkin example: Time to catch up with genetics. JAMA Neurol 2013;70:1186-1191. (IF: 7.0)
  5. Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, …, Klein C. PTEN-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem (iPS) cell-derived neurons. J Biol Chem 2013;288:2223-2237. (IF: 4.6)
  6. Morais VA, Haddad D, Craessaerts K, …, Grünewald A, …, De Strooper B. PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science 2014;344:203-207. (IF: 33.6)
  7. Grünewald A, Arns B, Meier B, …, Klein C. Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated PD? Antioxid Redox Signal 2014;20:1955-1960. (IF: 7.4)
  8. Deuse T, Wang D, Stubbendorff M, …, Grünewald A, …, Schrepfer S. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell 2015;16:33-38. (IF:22.3)
  9. Grünewald A, Rygiel KA, Hepplewhite PD, et al. Mitochondrial DNA depletion in respiratory chain- deficient Parkinson disease neurons. Ann Neurol; in press. (IF: 10.0)
  10. Grünewald A, Klein C. Urinary LRRK2 phosphorylation: Penetrating the thicket of Parkinson disease? Neurology; in press. (IF: 8.3)