ALEKSANDAR RAKOVIC

 

PERSONAL INFORMATION

Position/Title: Research Group Leader (Institute of Neurogenetics), PhD

Address University of Lübeck; Ratzeburger Allee 160, 23538 Lübeck, Germany

Tel: +49-451-2903352; Fax: +49-451-2903355

@:aleksandar.rakovic@neuro.uni-luebeck.de; www.neurogenetics-luebeck.de

 

EDUCATION/POSITIONS

1995-2005 Studies of Biology (University of Belgrade, Belgrade, Serbia)

2006-2007 PhD Thesis (Laboratory for Radiobiology and Molecular Genetics, Institute of Nuclear Sciences, Belgrade, Serbia)

2007-2011 PhD Thesis (Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany)

2011-2013 Postdoctoral Researcher (Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Germany)

2016-2017 Research Fellow (SickKids, University of Toronto, Canada)

2013-present Leader of the research group “Molecular mechanisms of Parkinson’s disease” (Institute of Neurogenetics, University of Lübeck)

2019 Habilitation submitted

 

ACADEMIC ACTIVITIES

2013-present Ad hoc reviewer (Annals of Neurology)

2013-present Reviewer (DFG, The Telethon Foundation)

AWARDS

2007 Scholarship from Department of Neurology, University of Lübeck, Germany

2007 Scholarship from German Academic Exchange Service (DAAD)

2011 Travel award from the Movement Disorder Society (MDS)

2014 Prize for the Best Doctoral Thesis in the MINT Section (Mathematics, Engineering, Natural, and Technical Sciences) of the University of Lübeck

 

SELECTED PUBLICATIONS

From 37 original publications; total citations: 1,249; h-index: 16

      1. Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137. [IF: 8.1]
      2. Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C. Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J Biol Chem 2013;288:2223-37. [IF: 4.6]
      3. Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature 2014;509:641-4
        [IF: 41.5]
      4. Rakovic A, Domingo A, Grütz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Brüggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, König I, Klein C. Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Mov Disord 2018;33:1108-1118. [IF: 8.3]
      5. Zanon A, Kalvakuri S, Rakovic A (equally contributing first author), Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I, Seibler P. SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet 2017;26:2412-2425. [IF: 4.9]
      6. Prasuhn J, Mårtensson CU, Krajka V, Klein C, Rakovic A. Genome-Edited, TH-expressing Neuroblastoma Cells as a Disease Model for Dopamine-Related Disorders: A Proof-of-Concept Study on DJ-1-deficient Parkinsonism. Front Cell Neurosci 2018;11:426. [IF: 3.9]
      7. Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Madoev H, Park JS, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A. Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants. Hum Mutat 2018;39:1901-1915. [IF: 4.5]
      8. McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife 2018;7. [IF: 7.6]
      9. Chakraborty J, von Stockum S, Marchesan E, Caicci F, Ferrari V, Rakovic A, Klein C, Antonini A, Bubacco L, Ziviani E. USP14 inhibition corrects an in vivo model of impaired mitophagy. EMBO Mol Med 2018;10. [IF: 10.6]
      10. Rakovic A, Ziegler J, Mårtensson CU, Prasuhn J, Shurkewitsch K, König P, Paulson HL, Klein C. PINK1-dependent mitophagy is driven by the UPS and can occur independently of LC3 conversion. Cell Death Differ 2019;26:1428-1441. [IF: 8.1]